On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

Autor:	David B, Chou, Viktoras, Frismantas, Yuka, Milton, Rhiannon, David, Petar, Pop-Damkov, Douglas, Ferguson, Alexander, MacDonald, Özge, Vargel Bölükbaşı, Cailin E, Joyce, Liliana S, Moreira Teixeira, Arianna, Rech, Amanda, Jiang, Elizabeth, Calamari, Sasan, Jalili-Firoozinezhad, Brooke A, Furlong, Lucy R, O'Sullivan, Carlos F, Ng, Youngjae, Choe, Susan, Marquez, Kasiani C, Myers, Olga K, Weinberg, Robert P, Hasserjian, Richard, Novak, Oren, Levy, Rachelle, Prantil-Baun, Carl D, Novina, Akiko, Shimamura, Lorna, Ewart, Donald E, Ingber
Rok vydání:	2018
Předmět:	Bone Marrow Lab-On-A-Chip Devices Microfluidics Animals Humans Antigens CD34 Bone Marrow Cells Cell Differentiation Mesenchymal Stem Cells Cells Cultured Bone Marrow Transplantation Cell Proliferation Hematopoiesis
Zdroj:	Nature biomedical engineering. 4(4)
ISSN:	2157-846X
Popis:	The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show that a vascularized human BM-on-a-chip (BM chip) supports the differentiation and maturation of multiple blood cell lineages over 4 weeks while improving CD34
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6d2a85e035f2f84beeeb22fcf2ce3dde https://pubmed.ncbi.nlm.nih.gov/32286508 Zobrazit plný text záznamu Full text from SpringerLink