| Autor: |
J, Fujita, J R, Mestre, J B, Zeldis, K, Subbaramaiah, A J, Dannenberg |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(11) |
| ISSN: |
1078-0432 |
| Popis: |
We investigated the effect of thalidomide, a compound with immunomodulatory and antiangiogenic properties, on lipopolysaccharide (LPS)-mediated induction of cyclooxygenase-2 (Cox-2) and prostaglandin (PG) biosynthesis in murine macrophages. Thalidomide caused a dose-dependent inhibition of LPS-mediated induction of PGE(2) synthesis in RAW 264.7 cells. The induction of Cox-2 protein and mRNA by LPS was also suppressed by thalidomide. Based on the results of nuclear run-off assays and transient transfections, treatment with LPS stimulated Cox-2 transcription, an effect that was unaffected by thalidomide. Thalidomide decreased the stability of Cox-2 mRNA. A series of structural analogues of thalidomide also inhibited LPS-mediated induction of Cox-2 and PGE(2) synthesis. Taken together, these data provide new insights into the antineoplastic and anti-inflammatory properties of thalidomide. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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