| Autor: |
Nela, Kelam, Anita, Racetin, Mirjana, Polović, Benjamin, Benzon, Marin, Ogorevc, Katarina, Vukojević, Merica, Glavina Durdov, Ana, Dunatov Huljev, Ivana, Kuzmić Prusac, Davor, Čarić, Fila, Raguž, Sandra, Kostić |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International journal of molecular sciences. 23(24) |
| ISSN: |
1422-0067 |
| Popis: |
This study aimed to explore the spatio-temporal expression patterns of congenital anomalies of kidney and urinary tract (CAKUT) candidate genes, Fibroblast Growth Factor Receptor 1 (FGFR1), Fibroblast Growth Factor Receptor 2 (FGFR2) and Receptor-Interacting Protein Kinase 5 (RIP5), in human fetal kidney development (CTRL) and kidneys affected with CAKUT. Human fetal kidneys from the 22nd to 41st developmental week (duplex, hypoplastic, dysplastic, and controls) were stained with antibodies and analyzed by epifluorescence microscopy and RT-qPCR. The effect of CAKUT candidate genes on kidney nephrogenesis and function is confirmed by statistically significant variations in the spatio-temporal expression patterns of the investigated markers. The nuclear localization of FGFR1, elevated expression score of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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