| Autor: |
Kuang-Qi, Chen, Bang-Hong, Wei, Shuang-Li, Hao, Wan-Xi, Yang |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Histology and histopathology. 37(7) |
| ISSN: |
1699-5848 |
| Popis: |
The PI3K/AKT signaling pathway is one of the most crucial regulatory mechanisms in animal cells, which can mainly regulate proliferation, survival and anti-apoptosis in cell lines. In the seminiferous epithelium, most studies were concentrated on the role of PI3K/AKT signaling in immature Sertoli cells (SCs) and spermatogonia stem cells (SSCs). PI3K/AKT signaling can facilitate the proliferation and anti-apoptosis of immature Sertoli cells and spermatogenic cells. Besides, in mature Sertoli cells, this pathway can disintegrate the structure of the blood-testis barrier (BTB) via regulatory protein synthesis and the cytoskeleton of Sertoli cells. All of these effects can directly and indirectly maintain and promote spermatogenesis in male testis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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