Insect neuropeptide proctolin and its analogues. An overview of the present literature

Autor:	D, Konopińska
Rok vydání:	1997
Předmět:	Analgesics Neurotransmitter Agents Structure-Activity Relationship Insecta Protein Conformation Muscles Neuropeptides Animals Humans Cardiovascular Agents Amino Acid Sequence Oligopeptides Rats
Zdroj:	The journal of peptide research : official journal of the American Peptide Society. 49(6)
ISSN:	1397-002X
Popis:	In the present paper, the literature describing synthetic, biological and conformational studies on the insect neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) and its analogues is summarized. The paper covers proctolin and its 80 analogues modified in positions 1-5, a cycloanalogue and analogues with a truncated or elongated peptide chain. These peptides were bioassayed by different methods, e.g. studies of myotropic activities in several insect species in vitro and behaviour in rats in vivo. Based on these data structure-activity relationships are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6cfd32bb61b464da35de5b96f7950e16 https://pubmed.ncbi.nlm.nih.gov/9266472 Zobrazit plný text záznamu Plný text