Adrenocorticotropin production by a mammary carcinoma

Autor:	B H, Woodard, G, Eisenbarth, N R, Wallace, J A, Mossler, K S, McCarty
Rok vydání:	1981
Předmět:	Immunoenzyme Techniques Carcinoma Intraductal Noninfiltrating Adrenocorticotropic Hormone Receptors Estrogen Histocytochemistry Humans Adrenalectomy Breast Neoplasms Female Cytoplasmic Granules Paraneoplastic Endocrine Syndromes
Zdroj:	Cancer. 47(7)
ISSN:	0008-543X
Popis:	A patient with clinical hypercortisolism and an infiltrating ductal carcinoma of the right mammary gland is presented. Provocative testing of adrenal function demonstrated the pattern of ectopic adrenocorticotropic hormone (ACTH) production. Ultrastructural analysis of the tumor revealed 150-200 nm electron-dense granules that when primarily fixed in OsO4 appeared as membrane-bound, centrally dense cored granules. ACTH was extracted from the tumor tissue and immunocytochemically localized in the tumor cell cytoplasm. A clinically significant level of estrogen receptor protein was present in the tumor tissue (120 fmol/mg protein). This case confirms the ability of mammary carcinoma to produce the ectopic ACTH syndrome.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6cf23ac47408f3a456df4a439911a4d4 https://pubmed.ncbi.nlm.nih.gov/6261928 Zobrazit plný text záznamu Plný text