[Treatment duration of extra-pulmonary tuberculosis: 6 months or more? TB-INFO database analysis]
| Autor: | S, Bouchikh, J, Stirnemann, V, Prendki, R, Porcher, H, Kesthmand, A-S, Morin, P, Cruaud, S, Rouaghe, D, Farge, O, Fain |
|---|---|
| Jazyk: | francouzština |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Aged 80 and over Male Paris Time Factors AIDS-Related Opportunistic Infections Adolescent Databases Factual Antitubercular Agents HIV Infections Continuity of Patient Care Middle Aged Drug Administration Schedule Cohort Studies Young Adult Data Interpretation Statistical Humans Patient Compliance Tuberculosis Female Algorithms Aged Retrospective Studies |
| Zdroj: | La Revue de medecine interne. 33(12) |
| ISSN: | 1768-3122 |
| Popis: | The recommended duration of pulmonary tuberculosis therapy is 6 months. For extrapulmonary tuberculosis, treatment duration depends on tuberculosis involvement and HIV status. The objective of this study was to describe the main characteristics of a cohort of extrapulmonary tuberculosis patients, to compare patients with a 6-month treatment to those with more than a 6-month treatment, and to analyze the compliance of medical centres with recommended duration of treatment.A retrospective cohort study of 210 patients with extrapulmonary tuberculosis was carried from January 1999 to December 2006 in two hospitals in the north-east of Paris. These patients were treated with quadruple therapy during two months, followed by dual therapy during 4 months (n=77) or more (n=66). The characteristics of each group were compared by uni- and multivariate analysis. The primary endpoint was the rate of relapse or treatment failure at 24-month follow-up after treatment completion.No relapse was observed after 24 months of follow-up after the end of treatment in the two groups. In univariate analysis, patients with lymph node tuberculosis were more often treated for 6 months than at other sites of tuberculosis (respectively 61% versus 40.9%; P=0.02); the decision of treatment duration was related to medical practices (79.2% treated 6 months in one hospital versus 20.7% in the other, P0.001); patients living in private residence were more often treated during 6 months than patients living in residence (24.2% versus 10.3%, P=0.042). In multivariate analysis, only hospital (P=0.046), sex (P=0.007) and private residence were significantly different in each group.A period of 6 months seems to be sufficient to treat extrapulmonary tuberculosis (except for neuromeningeal localization). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect