| Autor: |
Melanie, Cree-Green, Bryan C, Bergman, Gregory V, Coe, Lindsey, Newnes, Amy D, Baumgartner, Samantha, Bacon, Ann, Sherzinger, Laura, Pyle, Kristen J, Nadeau |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Obesity (Silver Spring, Md.). 24(11) |
| ISSN: |
1930-739X |
| Popis: |
Increased liver fat and type 2 diabetes are prevalent in women with polycystic ovarian syndrome (PCOS) and cause excess mortality, yet little is known about their development during adolescence. The objective of this study was to measure hepatic steatosis and related metabolic contributors in girls with obesity, with and without PCOS.Nondiabetic adolescents with obesity, 41 with PCOS (PCOS; age 15.0 [13.0-16.0] years, BMI 35.2 ± 0.61 kg/mForty-nine percent of the PCOS group had hepatic steatosis versus fourteen percent of the OB group (P = 0.02), and the PCOS group had higher N7 (43 ± 4 vs. 29 ± 5 nmol/g; P = 0.02). Peripheral IS was lower in PCOS (9.4 [7.2-12.3] vs. 14.5 [13.1-18.05 mg/lean kg/min]; P0.001) as was hepatic (P = 0.006) and adipose IS (P = 0.005). Percent liver fat correlated with N7 (R = 0.46, P = 0.02) and visceral fat (R = 0.42, P0.001), not androgens or peripheral IS.Nearly 50% of nondiabetic girls with PCOS and obesity have hepatic steatosis, which relates to visceral fat and lipogenesis, but not to IS or androgens. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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