Monomicrobial Fournier's Gangrene Caused by Panton-Valentine Leukocidin-negative Methicillin-susceptible Staphylococcus aureus ST8 in Japan
| Autor: | Hirofumi, Yamagishi, Kenichi, Kawahori, Noriaki, Ohkiba, Nozomi, Murooka, Takeshi, Inazawa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Staphylococcus aureus Superantigens Genotype Virulence Factors methicillin-susceptible Staphylococcus aureus ST8 Bacterial Toxins Case Report biochemical phenomena metabolism and nutrition Staphylococcal Infections bacterial infections and mycoses Panton-Valentine leukocidin Enterotoxins Methicillin Japan Fournier's gangrene Leukocidins toxic shock syndrome toxin-1 Humans skin and connective tissue diseases Fournier Gangrene Aged |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 |
| Popis: | Methicillin-resistant Staphylococcus aureus USA300, belonging to sequence type (ST) 8, is a rare cause of necrotizing fasciitis in the USA. We herein report a case of monomicrobial Fournier's gangrene caused by an ST8, methicillin-susceptible Staphylococcus aureus (designated ksw1). Whole-genome sequencing and analyses for virulence determinants revealed that, unlike USA300, ksw1 lacked virulence genes, such as Panton-Valentine leukocidin and SCCmec, while harboring the toxic shock syndrome toxin-1 gene. These genomic features correlate with ST8 CA-MRSA/J, which is the major genotype of ST8 in Japan. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|