| Autor: |
Rajkumar, Rajanathan, Tina Myhre, Pedersen, Morten B, Thomsen, Hans Erik, Botker, Vladimir V, Matchkov |
| Rok vydání: |
2021 |
| Zdroj: |
Frontiers in physiology. 13 |
| ISSN: |
1664-042X |
| Popis: |
Investigating the cardiovascular system is challenging due to its complex regulation by humoral and neuronal factors. Despite this complexity, many existing research methods are limited to the assessment of a few parameters leading to an incomplete characterization of cardiovascular function. Thus, we aim to establish a murineWe hypothesize that (i) ourWe included 12 mice that were randomly assigned to either vehicle or phenylephrine intervention through intraperitoneal administration. Mice were anesthetized with isoflurane and intubated endotracheally for mechanical ventilation. We measured blood pressurePhenylephrine significantly increased blood pressure, stroke volume, and total peripheral resistance compared to the vehicle group. Moreover, heart rate was significantly decreased following phenylephrine administration. Pacing significantly decreased stroke volume and cardiac output both prior to and after drug administration. However, phenylephrine-induced changes in blood pressure and total peripheral resistance were maintained with increasing pacing frequencies compared to the vehicle group. Total peripheral resistance was not significantly altered with increasing pacing frequencies suggesting that the effect of phenylephrine is primarily of vascular origin.In conclusion, this |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
