Platinum-based combination chemotherapy vs. weekly cisplatin during adjuvant CCRT in early cervical cancer with pelvic LN metastasis
Autor: | Yoo-Young, Lee, Won, Park, Seung Jae, Huh, Aera, Yoon, Jin-Young, Park, Chel Hun, Choi, Tae-Joong, Kim, Jeong-Won, Lee, Byoung-Gie, Kim, Duk-Soo, Bae |
---|---|
Rok vydání: | 2013 |
Předmět: |
Adult
Uterine Cervical Neoplasms Chemoradiotherapy Adjuvant Kaplan-Meier Estimate Middle Aged Disease-Free Survival Carboplatin Pelvis Consolidation Chemotherapy Area Under Curve Lymphatic Metastasis Antineoplastic Combined Chemotherapy Protocols Carcinoma Squamous Cell Humans Female Fluorouracil Lymph Nodes Cisplatin Cyclophosphamide Aged Proportional Hazards Models Retrospective Studies |
Zdroj: | Anticancer research. 33(10) |
ISSN: | 1791-7530 |
Popis: | Adjuvant concurrent chemoradiation (CCRT) should be considered in surgically-treated patients with early-stage cervical cancer (ECC) who exhibit pelvic lymph node (LN) metastasis. Platinum-based chemotherapy is usually recommended during adjuvant CCRT, however, it is unclear which regimen has better prognostic outcomes.We reviewed the electronic medical records to find patients with primary ECC (FIGO stages IB-IIA) who underwent type III radical hysterectomy and adjuvant CCRT due to pelvic LN metastasis at the Samsung Medical Center, Sungkyunkwan University School of Medicine in Seoul, Korea, from November 1997 to September 2007.Among 75 patients, 34 received weekly cisplatin. Combination chemotherapy was performed without consolidation in 21 patients and with consolidation in 20 patients. The mean follow-up period was 59.0 months and the five-year survival rate was 84.4%. In multivariate analysis, combination chemotherapy with and without consolidation was associated with improved disease-free survival [hazard ratio (HR)=0.23, 95% confidence interval (CI)=0.06-0.88, p=0.032, and HR=0.29, 95% CI=0.09-0.91, p=0.034, respectively]; combination chemotherapy with consolidation significantly improved overall survival (HR=0.11, 95% CI=0.02-0.87, p=0.037) when compared to weekly cisplatin.We found that platinum-based combination chemotherapy during adjuvant CCRT after surgery promoted better survival than a weekly cisplatin regimen in ECC patients with pelvic LN metastasis. |
Databáze: | OpenAIRE |
Externí odkaz: |