Genome sequence, comparative analysis and population genetics of the domestic horse (Equus caballus)
| Autor: | Wade, CM, Giulotto, E, Sigurdsson, S, Zoli, M, Gnerre, S, Imsland, F, Lear, TL, Adelson, DL, Bailey, E, Bellone, RR, Blöcker, H, Distl, O, Edgar, RC, Garber, M, Leeb, T, Mauceli, E, MacLeod, JN, Penedo, MCT, Raison, JM, Sharpe, T, Vogel, J, Andersson, L, Antczak, DF, Biagi, T, Binns, MM, Chowdhary, BP, Coleman, SJ, Della Valle, G, Fryc, S, Guérin, G, Hasegawa, T, Hill, EW, Jurka, J, Kiialainen, A, Lindgren, G, Liu, J, Magnani, E, Mickelson, JR, Murray, J, Nergadze, SG, Onofrio, R, Pedroni, S, Piras, MF, Raudsepp, T, Rocchi, M, Røed, KH, Ryder, OA, Searle, S, Skow, L, Swinburne, JE, Syvänen, AC, Tozaki, T, Valberg, SJ, Vaudin, M, White, JR, Zody, MC, Lander, ES, Lindblad-Toh, K |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Genome
DNA Copy Number Variations Centromere Molecular Sequence Data Chromosome Mapping Computational Biology Sequence Analysis DNA Chromosomes Mammalian Synteny Article Evolution Molecular Dogs Genes Haplotypes Animals Domestic Animals Humans Female Horses Phylogeny Repetitive Sequences Nucleic Acid |
| Popis: | We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive, but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements – 48% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary novel centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise prior to satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|