| Autor: |
Nathan, Malka, Mukedaisi, Abulizi, Mounira, Kharoubi, Silvia, Oghina, Arnault, Galat, Fabien, Le Bras, Anissa, Moktefi, Soulef, Guendouz, Valérie, Molinier-Frenkel, Pascale, Fanen, Benoît, Funalot, Jean-Pascal, Lefaucheur, Paul, Blanc-Durand, Jean-François, Deux, Vincent, Audard, Diane, Bodez, Emmanuel, Itti, Thibaud, Damy |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
European journal of nuclear medicine and molecular imaging. 47(10) |
| ISSN: |
1619-7089 |
| Popis: |
Increased cardiac uptake (CU) on early-phaseWe reviewed all patients referred for suspicion of CA, who underwentOf 308 eligible patients, 247 had CA, including 75 ATTRv, 107 ATTRwt, and 65 light-chain (AL), while 61 had another cardiopathy (controls). ECU was observed in 29% of CA and 3% of controls. Most frequent sites of ECU were pleuropulmonary (16% of CA, 3% of controls) followed by the digestive tract and subcutaneous tissues. The liver and spleen ECU was only observed in AL-CA (n = 8). CU was only observed in CA patients (n = 187), of whom 182 had ATTR-CA vs. 5 AL-CA, P 0.001. MADI0 was only observed in controls (97%) and in AL-CA (60%). MADI1 was mainly observed in AL-CA (positive predictive value, PPV = 91%) while MADI2/3 were more frequent in ATTR-CA (PPV = 97%), P 0.0001. MADI 0 vs. MADI0 in AL and MADI3 vs. MADI2 in ATTR were associated with a worse prognosis (P = 0.03 and P = 0.002, respectively).ECU combined with CU demonstrates high diagnostic and prognostic values in CA patients. MADI seems an easy and reliable score in clinical practice. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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