Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels

Autor:	Kathleen H, Mortell, David J, Anderson, James J, Lynch, Sherry L, Nelson, Kathy, Sarris, Heath, McDonald, Reza, Sabet, Scott, Baker, Prisca, Honore, Chih-Hung, Lee, Michael F, Jarvis, Murali, Gopalakrishnan
Rok vydání:	2005
Předmět:	Protein Subunits Structure-Activity Relationship Molecular Structure Animals Pain Benzene Calcium Channels Amino Acids Calcium Channel Blockers Ligands Rats
Zdroj:	Bioorganicmedicinal chemistry letters. 16(5)
ISSN:	0960-894X
Popis:	A series of alpha-amino acids were identified as ligands which compete with gabapentin for binding to the alpha(2)delta subunit of voltage-dependent Ca(2+) channels. Potent analogs were identified. Their activity in an in vivo pain assay is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6c38cfc851c2e0ef07f554fb7434f4f2 https://pubmed.ncbi.nlm.nih.gov/16380257 Zobrazit plný text záznamu Full Text from ScienceDirect