| Autor: |
Yang, Hu, Liu-Sheng, Wang, Yue-Ping, Jin, Shan-Shan, Du, Yu-Kui, Du, Xian, He, Dong, Weng, Ying, Zhou, Qiu-Hong, Li, Li, Shen, Fen, Zhang, Yi-Liang, Su, Xiao-Li, Sun, Jing-Jing, Ding, Wen-Hui, Zhang, Hou-Rong, Cai, Hua-Ping, Dai, Jing-Hong, Dai, Hui-Ping, Li |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
The clinical respiratory journal. 11(3) |
| ISSN: |
1752-699X |
| Popis: |
The purpose of this study was to determine the diagnostic and prognostic values of serum KL-6 levels in Chinese patients with interstitial lung disease (ILDs).A total of 1084 subjects including 373 cases of ILDs, 584 cases of non-ILD pulmonary diseases, and 127 healthy individuals were recruited from three clinical centers in China between January 2011 and December 2013. A total of 106 patients undergoing treatments for ILDs in Shanghai Pulmonary Hospital between January 2011 and December 2013 were enrolled. Baseline and posttreatment serum KL-6 levels were determined.Serum KL-6 levels in patients with ILDs were significantly higher than those in patients with non-ILD pulmonary diseases or in healthy individuals (1492.09 ± 2230.08 U/mL vs 258.67 ± 268.73 U/mL or 178.73 ± 71.17 U/mL, all P 0.05). At the cut-off value of 500 U/mL, the sensitivity and specificity of serum KL-6 as a diagnostic marker for ILDs was 77.75% and 94.51%, respectively. The Kappa value was 0.743 (P 0.001). The area below the receiver operating characteristic curve was 0.922 with a 95% Confidence interval of 0.904-0.941 (P 0.001). The posttreatment serum KL-6 levels significantly reduced in patients with improved ILDs, whereas markedly increased in patients with exacerbated ILDs (All P 0.05).Serum KL-6 levels might be a promising diagnostic biomarker for ILDs in Chinese patients. The prognostic value of serum KL-6 levels for ILDs remains to be verified by large-scaled studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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