Symptoms that are associated with decreased pancreatic enzyme flow: MRCP assessment

Autor: Akira, Yamamoto, Katsuyoshi, Ito, Kazuya, Yasokawa, Akihiko, Kanki, Daigo, Tanimoto, Minoru, Hayashida, Tsutomu, Tamada
Rok vydání: 2018
Předmět:
Zdroj: Journal of magnetic resonance imaging : JMRI. 50(2)
ISSN: 1522-2586
Popis: Pancreatic exocrine insufficiency is one of the causes of malabsorption syndrome. In many cases of malabsorption syndrome, pancreatic exocrine insufficiency can be treated with pancreatic enzyme replacement therapy. Therefore, it is important to detect pancreatic endocrine insufficiency as early and accurately as possible. Recent studies have shown that cine-dynamic MR cholangiopancreatography (MRCP) may be useful to evaluate pancreatic exocrine function PURPOSE: To identify abdominal symptoms that suggest decreased flow of pancreatic enzyme secretion for which cine-dynamic MRCP should be performed to diagnose pancreatic exocrine insufficiency.Prospective.In all, 111 patients with various types of abdominal symptoms.5 T or 3 T, MRCP with spatially selective inversion recovery pulse (cine-dynamic MRCP).Cine-dynamic MRCP was performed and an 18-question clinical questionnaire on abdominal symptoms was administered. The secretion grade derived from cine-dynamic MRCP was compared between those answering "yes" and "no" for all 18 items STATISTICAL TESTS: Univariate analysis and further analyzed using multiple regression analysis. The associations between the secretion grade and the items in the clinical questionnaire were analyzed by univariate analysis and further analyzed using multiple regression analysis.The following three items showed significantly negative correlations with secretion grade: Q9, Does your rectal gas smell foul? (β = -0.44, P = 0.001); Q13, Is stool quantity large? (β = -0.41, P = 0.001); and Q18, Are your stools soft? (β = -0.53, P0.001). No significant correlations with exocrine pancreatic function measured by cine-dynamic MRCP were seen for the remaining 15 abdominal symptom items.Abdominal symptoms that suggest decreased flow of pancreatic enzyme secretion were foul rectal gas, large stool, and soft stool. Pancreatic exocrine insufficiency due to decreased pancreatic enzyme flow may be suspected in patients with these abdominal symptoms.1 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:417-423.
Databáze: OpenAIRE
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