| Autor: |
Julie, Jarand, Karen, Shean, Max, O'Donnell, Marian, Loveday, Charlotte, Kvasnovsky, Martie, Van der Walt, Shahieda, Adams, Paul, Willcox, Justin, O'Grady, Alimuddin, Zumla, Keertan, Dheda |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Tropical medicineinternational health : TMIH. 15(10) |
| ISSN: |
1365-3156 |
| Popis: |
To determine the clinical profile and outcomes of health care workers (HCWs) with extensively drug resistant tuberculosis (XDR-TB) in the Eastern and Western Cape Provinces of South Africa.Retrospective case record review of 334 patients with XDR-TB reported during the period 1996-2008 from Western and Eastern Cape Province, Cape Town, South Africa. Case records of HCWs with XDR-TB were analysed for clinical and microbiological features, and treatment outcomes.From 334 case records of patients with XDR-TB, 10 HCWs were identified. Eight of ten were HIV-uninfected, and four of 10 had died of XDR-TB despite treatment. All 10 HCWs had received an average of 2.4 courses of TB treatment before being diagnosed as XDR-TB.In the Eastern and Western Cape provinces of South Africa XDR-TB affects HCWs, is diagnosed rather late, does not appear to be related to HIV status and carries a high mortality. There is an urgent need for the South African government to implement WHO infection control recommendations and make available rapid drug susceptibility testing for HCWs with suspected multidrug-resistant (MDR)/XDR-TB. Further studies to establish the actual risk and sources of infection (nosocomial or community) are required. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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