Congenital central hypoventilation syndrome and desogestrel: a call for caution: addendum to 'C. Straus, H. Trang, M.H. Becquemin, P. Touraine, T. Similowski, Chemosensitivity recovery in Ondine's curse syndrome under treatment with desogestrel' [Respir. Physiol. Neurobiol. 171 (2010) 171-174]

Autor:	Christian, Straus, Thomas, Similowski
Rok vydání:	2011
Předmět:	Desogestrel Treatment Outcome Contraindications Humans Hypoventilation Recovery of Function Carbon Dioxide Sleep Apnea Central Chemoreceptor Cells
Zdroj:	Respiratory physiologyneurobiology. 178(2)
ISSN:	1878-1519
Popis:	Patients suffering from congenital central hypoventilation syndrome (CCHS) depend on mechanical ventilation during sleep, from birth and throughout life. They lack CO₂-chemosensitivity. Hope has recently been raised by serendipitous observations of chemosensitivity recovery under treatment by desogestrel, a very potent progestin (Straus et al., 2010). Caution is however needed, because this effect could depend on dose, idiosyncrasies, or be transient. Desogestrel should not be prescribed to CCHS patients with a respiratory purpose until the results of a pending clinical trial (clinicaltrials.gov. NCT01243697) are available.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6ba8ba12e8856238c35b32f543f5c124 https://pubmed.ncbi.nlm.nih.gov/21801857 Zobrazit plný text záznamu Full Text from ScienceDirect