Factors affecting the production of (-)-mitorubrinic acid by Penicillium funiculosum

Autor:	K, Lesová, M, Sturdíková, M, Rosenberg
Rok vydání:	2001
Předmět:	Nitrogen Phenylalanine Fermentation Penicillium Benzoates Carbon Culture Media
Zdroj:	Journal of basic microbiology. 40(5-6)
ISSN:	0233-111X
Popis:	The optimum conditions for the production of (-)-mitorubrinic acid by mutant strain of Penicillium funiculosum CCM F-8080 were examined in shaken flask cultures. The highest production of this metabolite was achieved in a medium with glucose as the sole carbon source and (NH4)2HPO4 as the nitrogen source. The most suitable concentrations of the given sources for production of (-)-mitorubrinic acid are 80 g/l glucose and 2 g/l (NH4)2HPO4 (maximal production, 814.9 mg/l). We also observed the influence of concentration of L-phenylalanine and inorganic phosphate in culture medium on the production of (-)-mitorubrinic acid. The biological activity of mitorubrinic acid as trypsin inhibitor was determined (IC50 41.05 mumol/l).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6b7ba5851b0fb2c215e0b3f84c829d64 https://pubmed.ncbi.nlm.nih.gov/11199497 Zobrazit plný text záznamu Plný text