| Autor: |
Shinsuke, Sasada, Makoto, Kodaira, Tatsunori, Shimoi, Akihiko, Shimomura, Mayu, Yunokawa, Kan, Yonemori, Chikako, Shimizu, Yasuhiro, Fujiwara, Kenji, Tamura |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Anticancer research. 36(5) |
| ISSN: |
1791-7530 |
| Popis: |
No standard chemotherapy for adults with recurrent/refractory rhabdomyosarcoma (RMS) has yet been established. The present study aimed to assess the effect of ifosfamide and etoposide (IE) chemotherapy on previously treated RMS.Adults with recurrent/refractory RMS were treated with ifosfamide (1,800 g/m(2)/day), etoposide (100 mg/m(2)/day) and mesna (1,080 mg/m(2)/day) for 5 days. The effect and toxicity were evaluated by chart review.Fifteen patients, with a median age of 33 years (range=25-67 years), were treated with IE chemotherapy. A median of six cycles of chemotherapy were administered and an objective response was obtained in eight patients. The median progression-free survival was 5.2 months (95% confidence interval=2.3-6.7 months) and overall survival was 14.4 months (95% confidence interval=4.6-28.3 months). Toxicity greater than grade 3 was as follows: neutropenia in all patients, anemia in seven, thrombocytopenia in seven and febrile neutropenia in eight.IE chemotherapy could be an alternative optional treatment method in adults with recurrent/refractory RMS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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