| Autor: |
J M, Quattro, D D, Pollock, M, Powell, H A, Woods, D A, Powers |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Molecular marine biology and biotechnology. 4(3) |
| ISSN: |
1053-6426 |
| Popis: |
Gene duplication has produced two lactate dehydrogenase (LDH) isozymes, LDH-A and LDH-B, that are found in essentially all vertebrates. On the basis of the biochemical properties of the LDH-A and LDH-B isozymes, it has been suggested that each locus is orthologous among all vertebrates. However, phylogenetic studies have not supported a common evolutionary history among the LDH-A isozymes, particularly when those from lower vertebrates are examined. We present here the sequence of a muscle-type LDH from Fundulus heteroclitus, a teleost fish for which the LDH-B sequence has been determined and shown to be unrelated phylogenetically to tetrapod LDH-A isozymes. Although the sequence of the teleost muscle LDH shares certain features with the LDH-A of tetrapods, phylogenetic analyses do not support an orthologous relation among the LDH-A isozymes of teleost fish and tetrapod vertebrates. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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