Synthesis and pharmacological properties of some derivatives of 3-phenylimidazo[4,5-b]pyridine

Autor:	L, Kaczmarek, P, Nantka-Namirski, E, Moryl, E, Chojnacka-Wójcik
Rok vydání:	1990
Předmět:	Central Nervous System Male Analgesics Electroshock Chemical Phenomena Chemistry Physical Pyridines Imidazoles Rats Inbred Strains Motor Activity Body Temperature Rats Lethal Dose 50 Mice Animals Anticonvulsants Serotonin Antagonists Stereotyped Behavior
Zdroj:	Polish journal of pharmacology and pharmacy. 42(1)
ISSN:	0301-0244
Popis:	The one-pot synthesis and properties of some derivatives of 3-phenylimidazo [4,5-b]pyridine (4a-g) were described. The central action of compounds 4a, 4f and 4g has been investigated using behavioral tests in mice and rats. The tested compounds showed a potent sedative effect. Compound 4f has central serotoninolytic properties in the m-CPP induced hyperthermia in rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6b6f0b2797e1edf895ed8225300dc9d1 https://pubmed.ncbi.nlm.nih.gov/2281023 Zobrazit plný text záznamu