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The paper is devoted to a study of clinical manifestations of Kashin-Beck disease in 239 patients and biochemical indices of connective tissue metabolism in 103 patients with the same disease (all patients ranging in age from 10 to 75 at different stages of disease). Investigation of metabolism of collagen, glycosaminoglycans and glycoproteins showed a significant decrease in the levels of chondroitin sulfates, total oxyproline and urine fucose, protein-bound blood oxyproline and an increase in the levels of urine hyaluronic acid and blood fucose in stage I patients as compared to normal indices in healthy persons. More marked changes of these indices were revealed in disease progression. |
