Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes

Autor:	Chunyan, Wang, Emma L, Hesketh, Tatiana M, Shamorkina, Wentao, Li, Peter J, Franken, Dubravka, Drabek, Rien, van Haperen, Sarah, Townend, Frank J M, van Kuppeveld, Frank, Grosveld, Neil A, Ranson, Joost, Snijder, Raoul J, de Groot, Daniel L, Hurdiss, Berend-Jan, Bosch
Rok vydání:	2021
Předmět:	Coronavirus OC43 Human Epitopes SARS-CoV-2 Spike Glycoprotein Coronavirus Antibodies Monoclonal COVID-19 Humans Antibodies Viral Antibodies Neutralizing
Zdroj:	Nature communications. 13(1)
ISSN:	2041-1723
Popis:	Human coronavirus OC43 is a globally circulating common cold virus sustained by recurrent reinfections. How it persists in the population and defies existing herd immunity is unknown. Here we focus on viral glycoprotein S, the target for neutralizing antibodies, and provide an in-depth analysis of its antigenic structure. Neutralizing antibodies are directed to the sialoglycan-receptor binding site in S1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6b1c06a3b16bc6f9963dbb07fae24085 https://pubmed.ncbi.nlm.nih.gov/35614127 Zobrazit plný text záznamu Full text from SpringerLink