| Autor: |
L, Eidus, E, Glatthaar, M M, Hodgkin, E E, Nel, H H, Kleeberg |
| Rok vydání: |
1979 |
| Předmět: |
|
| Zdroj: |
International journal of clinical pharmacology and biopharmacy. 17(7) |
| ISSN: |
0340-0026 |
| Popis: |
Black tuberculosis patients from South Africa (S. A.) as well as from Birmingham, Alabama, U.S.A., showed a higher percentage of fast inactivators of isoniazid (INH) than that found in the North American white population, simultaneously sampled. In S. A. blacks, the frequency of fast inactivation was 57.9--59.6%, while in American blacks of Birmingham it amounted to 60.3%; in comparison to the above groups the rate of fast acetylators in Canadian Caucasians was 41.9% and in the USA white population 41.0%. For phenotyping of isoniazid inactivators a urine test was used. In this method the concentrations of INH (including isoniazidhydrazones) as well as acetylisoniazid were determined in the specimens collected 6--8 hrs following a test dose of 10 mg/kg INH. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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