| Autor: |
A T, Cheung, R B, Moss, A B, Leong, W J, Novick |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Journal of medical primatology. 21(7-8) |
| ISSN: |
0047-2565 |
| Popis: |
Host defense abnormalities in cystic fibrosis (CF) against Pseudomonas aeruginosa (PA) lead to excessive neutrophil influx into the infected lungs, resulting in pulmonary complications. We have developed a rhesus monkey model of chronic PA endobronchitis by intrabronchial instillation of PA-embedded agar beads, utilizing flexible fiberoptic bronchoscopy. Treatment of infected monkeys with pentoxifylline suppressed neutrophil influx and ameliorated pulmonary damage. The results suggest a method by which neutrophil influx and pulmonary damage in CF patients can be managed or prevented. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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