[Effect of the chronic use of propranolol on the specific binding of 3H-WB-4101 with the membranes of the mesenteric vessels in rats]

Autor:	Sh I, Ismailov, V V, Rozhanets, A V, Val'dman
Rok vydání:	1985
Předmět:	Male Time Factors Adrenergic beta-Antagonists Cell Membrane Synaptic Membranes Brain Rats Inbred Strains Receptors Adrenergic alpha Dioxins Tritium Propranolol Mesenteric Arteries Rats Dioxanes Mesenteric Veins Animals Adrenergic alpha-Antagonists
Zdroj:	Biulleten' eksperimental'noi biologii i meditsiny. 100(7)
ISSN:	0365-9615
Popis:	It has been shown that the 15-bay use of dl-propranolol (100 mg/kg a day) leads to a significant increase in the dissociation constant (CD) of the sites of specific binding of 3H-WB-4101 with membranes of rat mesenteric vessels. The concentration (Bmax) of the binding sites does not significantly change. Propranolol and other adrenoblockers do not possess any affinity for alpha-adrenoreceptors of rat brain synaptic membranes, i.e. changes in the properties of these receptors in vascular membranes cannot be accounted for by the direct action of propranolol in vivo or by the influence of the drug left in the membranes in vitro. It is concluded that desensitization of alpha1-adrenoreceptors of the peripheral vessels may be an essential element in the mechanism of the hypotensive action under the chronic use of beta-adrenoblockers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6ae3d60273481330edd22ab31ee87d32 https://pubmed.ncbi.nlm.nih.gov/2861863 Zobrazit plný text záznamu