| Autor: |
Andrew M, Lamade, Yaming, Chen, Carla J, Johnson, Hülya, Bayır, Robert S B, Clark |
| Rok vydání: |
2022 |
| Zdroj: |
Methods in molecular biology (Clifton, N.J.). 2609 |
| ISSN: |
1940-6029 |
| Popis: |
Poly(ADP-ribose) polymerases (PARP) participate in diverse biological processes contributing to cellular homeostasis or exacerbating injury. PARP catalyzes the addition of ADP-ribose molecules (pADPr) to the target proteins, a process termed poly-ADP-ribosylation. Overactivation of PARP - reflected by increased poly-ADP-ribosylation and accumulation of pADPr-modified proteins or free pADPr - contributes to depletion of NAD |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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