| Popis: |
In the perfusion model on Wistar rats the action of a single s. c. injection of betazol (Histalog) in a dose of 50 mg/kg b. w. in dependence on various types of stomach operations was studied. The following effects were observed: 1. the vagotomy shortly before the perfusion test did not reduce the effect of betazol. 2. If the vagotomy dated back at least 4 weeks, a reduction of the stimulated maximum secretion to half of the controls was seen. 3. The combination of the vagotomy with a pyloroplasty led to a reduction of the stimulated maximum acid secretion to half the amount. Futhermore, the betazol effect was shortened considerably and was demonstrable for no more than 2 h after the injection. 4. The antrectomy without vagotomy, however, casued a retardation of the answer to betazol with a maximum of the stimulated secretion in the 4th hour after s.c. injection. The dissociation of the effect of betazol caused by vagotomy or antrectomy leads to the conclusion that betazol has a direct site of action in the parietal cell and a second one in the cholinergic stimulation of the vagal system. |
