| Autor: |
Joyce F, Braam, Helene C A, Zondag, Alje P, van Dam, Henry J C, de Vries, Clarissa, Vergunst, David, Hetem, Maarten F, Schim van der Loeff, Sylvia M, Bruisten |
| Rok vydání: |
2023 |
| Zdroj: |
BMJ open. 12(12) |
| ISSN: |
2044-6055 |
| Popis: |
This study aimed to determine the prevalence of fluoroquinolone resistance-associated mutations (QRAMs) inA cross-sectional study.Between 2018 and 2019, 669 clients with MG were included from two previous studies: 375 male clients with urethritis from the SHC in Amsterdam; and 294 clients (male and female) from the SHC in Amsterdam and The Hague. Urogenital and anal samples (705 in total) that tested positive for MG by nucleic acid amplification tests were selected.The presence of QRAM was detected by an MG-QRAM PCR targeting four mutations in theWe found QRAM in 58 of 669 (9%) clients with an MG infection: 36 of 375 (10%) in the study population of men with urethritis and 22 of 294 (7%) in the study population of other clients (including both men and women; p=0.334). Most prevalent mutations in theNine per cent of MG-positive clients from two Dutch SHCs had QRAM. New treatment strategies and antibiotics are needed to treat symptomatic patients with multidrug-resistant MG. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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