| Autor: |
J P P M, De Vries, A, Karimi, B, Fioole, M, Van Leersum, D A B, Werson, D A F, Van Den Heuvel |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
The Journal of cardiovascular surgery. 54(3) |
| ISSN: |
1827-191X |
| Popis: |
The use of drug-eluting balloons for treatment of long-segment femoropopliteal artery obstructions has become widespread in recent years. The possibility to deliver a drug into the arterial wall with sustained antiproliferative effects, without leaving behind metal scaffolding, seems very promising. The current generation of drug-eluting balloons differs in the formulation of the drug (usually paclitaxel), technique of coating, and the elution excipients. Results of published randomized trials are reviewed in this report. A new innovative coating technique has been introduced recently. The PRIMUS® coronary drug-eluting balloon and the Legflow® peripheral drug-eluting balloon consist of paclitaxel nanoparticles that are embedded underneath the surface of the balloon as well as inside a new shellolic acid drug-release matrix. Risk for dislodgement of the paclitaxel particles is minimized in the newest generation of drug-eluting balloons. Short-term in vitro and in vivo results of this stable, coated balloon are promising, and large randomized trials have been started recently to gather more long-term and robust clinical data. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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