Insulin-induced changes of proteolytic activity of the lysosomal enzymes

Autor: Bozena, Witek, Ewa, Ochwanowska, Adam, Kolataj, Teodora, Król, Danuta, Baranowska, Jan, Rafay
Rok vydání: 2003
Předmět:
Zdroj: Neuro endocrinology letters. 25(1-2)
ISSN: 0172-780X
Popis: Changes in the activity of alanine aminopeptidase, leucine aminopeptidase and cathepsins D and L in the liver and kidney of male and female of mice, injected with 0.4 IU/kg b.w. insulin for 4 and 8 days.The homogenates of the liver and kidney were taken for examination. The activity of alanine aminopeptidase, leucine aminopeptidase and cathepsins D and L has been determined according to [1] method.The activity of alanine aminopeptidase, leucine aminopeptidase, cathepsins D and L in the liver and kidney of male and female of mice decreased in effect of insulin injections for 4 and 8 days.The changes of enzyme activities showed a stimulating effect of the insulin injection on the labilization of lysosomal membranes. The range of the reaction remained in a relationship with the kind of the organ, the type of enzyme, time over which insulin introduced operates in the organism, and with the sex.
Databáze: OpenAIRE