| Autor: |
S, Timme-Bronsert, P, Bronsert, M, Werner, B, Kulemann, J, Höppner |
| Jazyk: |
němčina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Der Pathologe. 39(Suppl 2) |
| ISSN: |
1432-1963 |
| Popis: |
Pancreatic ductal adenocarcinoma (PDAC) is a disease with a poor prognosis. PDAC shows characteristic mutations within codon 12/13. Circulating tumor cells (CTC) detected in blood samples of patients with cancer are hypothesized as the means of systemic tumor spread. But less is known about morphological/molecular characteristics or the pathophysiological meaning of PDAC CTC.The aim of the study was a cytomorphological and genetic analysis of CTC from patients with PDAC followed by the correlation of the results with those of the corresponding tumor in the pancreas.Blood samples of 58 patients with PDAC and 10 "normal" control donors were processed through a size-based CTC isolation. KRAS-mutation analyses were performed for CTC and the primary tumor and the results were compared. Furthermore, their potential as a prognostic marker was evaluated.In patients with different UICC stages CTC were detected, but not in normal control patients. There was a trend for a worse median overall survival (OS) for patients with3 CTC/ml. Patients with a KRASDetection and characterization of CTC (for example by KRAS mutation analysis) may be useful for prognosis. Furthermore, it expands our knowledge of tumor biology and may detect possible tumor heterogeneity regarding the mutation profile of some cancer types. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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