| Autor: |
Stacey N, Harbour, Daniel F, DiToro, Steven J, Witte, Carlene L, Zindl, Min, Gao, Trenton R, Schoeb, Gareth W, Jones, Simon A, Jones, Robin D, Hatton, Casey T, Weaver |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Sci Immunol |
| ISSN: |
2470-9468 |
| Popis: |
Acting in concert with TGF-β, IL-6 signaling induces Th17 cell development by programming Th17-related genes via STAT3. A role for IL-6 signaling beyond the inductive phase of Th17 cell development has not been defined, as IL-23 signaling downstream of Th17 cell induction also activates STAT3 and is thought responsible for Th17 cell maintenance. Here, we find that IL-6 signaling is required for both induction and maintenance of mouse Th17 cells; IL-6Rα–deficient Th17 cells rapidly lost their Th17 phenotype and did not cause disease in two models of colitis. Co-transfer of wild type Th17 cells with IL-6Rα–deficient Th17 cells induced colitis but was unable to rescue phenotype loss of the latter. High IL-6 expression in the colon promoted classic, or cis, rather than trans receptor signaling that was required for maintenance of Th17 cells. Thus, ongoing classic IL-6 signaling underpins the Th17 program and is required for Th17 cell maintenance and function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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