| Autor: |
Marzieh, Naseri, Ehsan, Ranaei Pirmardan, Seyed Javad, Mowla, Mehdi, Shamsara, Mansoreh, Movahedin, Saeideh, Nouri, Karim, Nayernia, Maryam, Kabir Salmani, Maryam, Shahali |
| Rok vydání: |
2022 |
| Zdroj: |
Iranian journal of biotechnology. 20(3) |
| ISSN: |
1728-3043 |
| Popis: |
The octamer-binding transcription factor-4 (OCT4) is known as an established important regulator of pluripotency, as well as a genetic "master switch" in the self-renewal of embryonic stem and germ cells.The present study developed a transgenic mouse model containing anTheThe results demonstrated the changes in sperm morphology, as well as a statistically significant decrease in the other sperm parameters (count, viability, and motility) and fertility rate (p0.05) in the transgenic mice compared with the control group. The assessment of the cause of the embryonic stem cell (ESC) death following transfection revealed a significant reduction in the endogenous OCT4 expression at both mRNA and protein levels in the transfected mESCs compared to the control ones.In general, the |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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