| Autor: |
T, Inaba, C, Shimazaki, T, Sumikuma, A, Okano, M, Hatsuse, A, Okamoto, R, Takahashi, E, Ashihara, S, Hibi, Y, Sudo, N, Yamagata, S, Murakami, K, Rin, N, Fujita, M, Yoshimura, M, Nakagawa |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
British journal of haematology. 109(3) |
| ISSN: |
0007-1048 |
| Popis: |
We performed the immunophenotyping of 101 patients with B-cell non-Hodgkin's lymphoma (B-NHL) using two-colour flow cytometry (FCM) and found that lymphoma cells coexpressed at least one kind of T-cell-associated antigen (T-Ag; CD2, CD5, CD7) in 25 patients (24. 8%). Among these three T-Ags, CD5 was the most frequently expressed, in 21 patients (20.8%), followed by CD7, expressed in five patients (5.0%), and CD2, which was expressed in two patients (2.0%). Two kinds of T-Ag were simultaneusly expressed in three patients (CD2/CD5, CD2/CD7, and CD5/CD7, each expressed in one patient). Concerning the expression pattern of T-Ag, there were no significant differences between lymph nodes and extranodal organs in the three patients with T-Ag-positive B-NHL (T-Ag(+) B-NHL) who were analysed. When comparing the clinical features between T-Ag(+) B-NHL and T-Ag-negative B-NHL (T-Ag(-) B-NHL), extranodal involvement and higher International Prognostic Index (H and H.I.) were significantly frequent in the former subgroup (P = 0.0119 and P = 0. 0302 respectively). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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