HIV-1 Evades a Gag Mutation that Abrogates KIR Binding and Disinhibits NK Cells in Infected Individuals with KIR2DL2(+)/HLA-C*03:04(+) Genotype

Autor:	Ziegler, Maja C., Naidoo, Kewreshini, Chapel, Anais, Nkotwana, Sindiswa, Mann, Jaclyn, Mncube, Zenele, Ismael, Nasreen, Goulder, Philip, Ndung’u, Thumbi, Altfeld, Marcus, Thobakgale, Christina F.
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Killer Cells Natural Genotype Receptors KIR Receptors KIR2DL2 Mutation HIV-1 Humans chemical and pharmacologic phenomena HIV Infections HLA-C Antigens Genes gag Article
Zdroj:	AIDS
Popis:	HIV-1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KIRs) to human leukocyte antigen class I (HLA-I) molecules modulating natural killer cell function. HIV-1 strains encoding amino acids that mediate binding of inhibitory KIRs might therefore have a selective benefit in individuals expressing the respective KIR/HLA genotypes. Here, we demonstrate that HIV-1 clade C avoids a p24 Gag mutation that abolishes binding of KIR2DL2 to HLA-C03:04 and disinhibits natural killer cells in individual encoding for this genotype.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::68f09b80864b3b38abc013ac36d55381 https://europepmc.org/articles/PMC7856308/ Zobrazit plný text záznamu