The Beneficial Effect of Anthocyanidin-Rich Vitis vinifera L. Grape Skin Extract on Metabolic Changes Induced by High-Fat Diet in Mice Involves Antiinflammatory and Antioxidant Actions
| Autor: | Gisele França, da Costa, Izabelle Barcellos, Santos, Graziele Freitas, de Bem, Viviane Silva Cristino, Cordeiro, Cristiane Aguiar, da Costa, Lenize Costa Reis Marins, de Carvalho, Dayane Teixeira, Ognibene, Angela Castro, Resende, Roberto Soares, de Moura |
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| Rok vydání: | 2017 |
| Předmět: |
Leptin
Male Anti-Inflammatory Agents Diet High-Fat Antioxidants Anthocyanins Mice Phosphatidylinositol 3-Kinases Animals Insulin Vitis Obesity Muscle Skeletal Inflammation Glucose Transporter Type 4 Interleukin-6 Plant Extracts Tumor Necrosis Factor-alpha Body Weight Polyphenols Mice Inbred C57BL Oxidative Stress Adipose Tissue Fruit Adiponectin Insulin Resistance |
| Zdroj: | Phytotherapy research : PTR. 31(10) |
| ISSN: | 1099-1573 |
| Popis: | We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by a high-fat diet (HFD). C57/BL6 mice were fed a standard diet (10% fat, control, and GSE groups) or an HFD (60% fat, high fat (HF), and HF + GSE) with or without GSE (200 mg/kg/day) for 12 weeks. GSE prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, and resistin; and the deregulation of leptin and adiponectin expression in adipose tissue. These beneficial effects of GSE may be related to a positive modulation of insulin signaling proteins (IR, pIRS, PI3K, pAKT), pAMPK/AMPK ratio, and GLUT4 expression in muscle and adipose tissue. In addition, GSE prevented the oxidative damage, evidenced by the restoration of antioxidant activity and decrease of malondialdehyde and carbonyl levels in muscle and adipose tissue. Finally, GSE showed an anti-inflammatory action, evidenced by the reduced plasma and adipose tissue inflammatory markers (TNF-α, IL-6). Our results suggest that GSE prevented the obesity and related metabolic disorders in HF-fed mice by regulating insulin sensitivity and GLUT4 expression as well as by preventing the oxidative stress and inflammation in skeletal muscle and adipose tissue. Copyright © 2017 John WileySons, Ltd. |
| Databáze: | OpenAIRE |
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