1-N-(Arylmaleamoyl)-3,5-bis(phenylmethylene)4-piperidones: a novel class of antimycobacterial agents

Autor:	A, Jha, J R, Dimmock
Rok vydání:	2006
Předmět:	Models Molecular Binding Sites Antitubercular Agents Microbial Sensitivity Tests Mycobacterium tuberculosis Piperidones
Zdroj:	Die Pharmazie. 61(6)
ISSN:	0031-7144
Popis:	Various acyl groups possessing markedly divergent topography were placed on the nitrogen atom of the antimycobacterial agent 3,5-bis(phenylmethylene)-4-piperidone (1). Some of the N-maleamoyl analogues of 1 displayed antitubercular properties thereby affording an insight into the structural requirements for interactions at a putative auxiliary binding site in the bacterium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::68d0944bbb60d0d1e53940a7bcacfe70 https://pubmed.ncbi.nlm.nih.gov/16826979 Zobrazit plný text záznamu