Physicochemical characteristics of carcinoembryonic antigen extracted from medullary carcinoma of the thyroid

Autor: A, Jullienne, C, Calmettes, M S, Moukhtar, G, Milhaud
Rok vydání: 1980
Předmět:
Zdroj: Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine. 1(3)
ISSN: 0167-1618
Popis: Carcinoembryonic antigen (CEA) and calcitonin (CT) were extracted from medullary carcinoma of the thyroid (MCT) tissues, fractionated on Sephacryl S-200 and chromatographed on Concanavalin A. CEA purified from MCT is closely related to CEA extracted from colonic tumors. It has an equivalent molecular weight, is a glycoprotein and has a similar electrophoretic mobility in both SDS and basic polyacrylamide electrophoresis. A certain degree of heterogeneity is present in the form of a smaller molecular weight component. Large molecular forms of CT which are present in MCT tissues and which co-elute with the minor component of CEA on Sephacryl chromatography can be separated by Concanavalin A chromatography.
Databáze: OpenAIRE