Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis

Autor:	Ako, Ishihara, Jun, Ishihara, Elyse A, Watkins, Andrew C, Tremain, Mindy, Nguyen, Ani, Solanki, Kiyomitsu, Katsumata, Aslan, Mansurov, Erica, Budina, Aaron T, Alpar, Peyman, Hosseinchi, Lea, Maillat, Joseph W, Reda, Takahiro, Kageyama, Melody A, Swartz, Eiji, Yuba, Jeffrey A, Hubbell
Rok vydání:	2019
Předmět:	Mice Encephalomyelitis Autoimmune Experimental Recombinant Fusion Proteins Injections Intravenous Animals Th17 Cells Female Interleukin-4 Lymph Nodes Immunosuppressive Agents Serum Albumin Spleen Half-Life
Zdroj:	Nature biomedical engineering. 5(5)
ISSN:	2157-846X
Popis:	Interleukin-4 (IL-4) suppresses the development of multiple sclerosis in a murine model of experimental autoimmune encephalomyelitis (EAE). Here, we show that, in mice with EAE, the accumulation and persistence in the lymph nodes and spleen of a systemically administered serum albumin (SA)-IL-4 fusion protein leads to higher efficacy in preventing disease development than the administration of wild-type IL-4 or of the clinically approved drug fingolimod. We also show that the SA-IL-4 fusion protein prevents immune-cell infiltration in the spinal cord, decreases integrin expression in antigen-specific CD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::68c43e02287c4911b22431ceb429eeff https://pubmed.ncbi.nlm.nih.gov/33093659 Zobrazit plný text záznamu Full text from SpringerLink