Folate-maytansinoids: target-selective drugs of low molecular weight

Autor:	C A, Ladino, R V, Chari, L A, Bourret, N L, Kedersha, V S, Goldmacher
Rok vydání:	1997
Předmět:	Folate Receptors GPI-Anchored Tumor Cells Cultured Humans Antineoplastic Agents Maytansine Receptors Cell Surface Drug Screening Assays Antitumor Carrier Proteins Fluorescent Antibody Technique Indirect KB Cells
Zdroj:	International journal of cancer. 73(6)
ISSN:	0020-7136
Popis:	Folate receptor is over-expressed in a variety of carcinomas. To design a cytotoxic drug that would selectively target these carcinomas, we synthesized folate-maytansinoids. These drugs showed high affinity toward folate receptor, appeared to enter cells exclusively via the folate receptor-mediated caveolar pathway and displayed high cytotoxic potency (in the range of 10[-11] to 10[-10] M) and remarkable selectivity for folate receptor-expressing carcinoma cell lines. Folate-maytansinoids represent a new class of tumor-specific agents in which the targeting and the cytotoxic function can be altered independently.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::68c0382c1a9f24b13843b95ea1cbe188 https://pubmed.ncbi.nlm.nih.gov/9399666 Zobrazit plný text záznamu Plný text