| Autor: |
E C, Borden, K, Kim, L, Ryan, R H, Blum, M, Shiraki, D C, Tormey, R L, Comis, R G, Hahn, D R, Parkinson |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Journal of interferon research. 12(6) |
| ISSN: |
0197-8357 |
| Popis: |
Interferons (IFNs)-alpha and -beta were administered to patients with metastatic sarcomas in two different Eastern Cooperative Oncology Group studies. In one study, patients received IFN-alpha 2b, 20 million units/m2 i.v. 5 days/week x 4, then 10 million units s.c.t.i.w. In the second study, patients received IFN-beta ser 180 million units t.i.w. Of 87 patients evaluable for response, there were three responses in 64 patients (5%) treated with IFN-alpha-2b and no responses in 23 patients treated with IFN-beta ser. Severe or life-threatening fatigue with decline in performance status complicated treatment of 37% of patients receiving IFN-alpha 2b and 17% of patients receiving IFN-beta ser. Further investigation of IFNs in sarcomas should depend on evidence from preclinical studies demonstrating synergistic effects of IFNs combined with a cytoreductive modality which has proven activity in these malignancies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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