The effect of cyclodextrins on the in vitro and in vivo properties of insulin-loaded poly (D,L-lactic-co-glycolic acid) microspheres

Autor:	José Maciel, Rodrigues Júnior, Karla, de Melo Lima, Carlos Eduardo, de Matos Jensen, Marta Maria Gontijo, de Aguiar, Armando, da Silva Cunha Júnior
Rok vydání:	2003
Předmět:	Male Cyclodextrins Drug Carriers Polymers In Vitro Techniques Microspheres Rats Mice Polylactic Acid-Polyglycolic Acid Copolymer Animals Insulin Lactic Acid Particle Size Powders Rats Wistar Polyglycolic Acid
Zdroj:	Artificial organs. 27(5)
ISSN:	0160-564X
Popis:	In this work we describe the development and characterization of a new formulation of insulin (INS). Insulin was complexed with cyclodextrins (CD) in order to improve its solubility and stability being available as a dry powder, after encapsulation into poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres. The complex INS : CD was encapsulated into microspheres in order to obtain particles with an average diameter between 2 and 6 microm. This system was able to induce significant reduction of the plasma glucose level in two rodent models, normal mice and diabetic rats, after intratracheal administration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::68be158086092dea43e45f25f99d3cdb https://pubmed.ncbi.nlm.nih.gov/12752215 Zobrazit plný text záznamu Plný text ve formátu PDF