| Autor: |
Harvey I, Pass, Marjan, Alimi, Michele, Carbone, Haining, Yang, Chandra M, Goparaju |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Thoracic surgery clinics. 30(4) |
| ISSN: |
1558-5069 |
| Popis: |
Malignant pleural mesothelioma (MPM) is an asbestos-related neoplasm that can only be treated successfully when correctly diagnosed and treated early. The asbestos-exposed population is a high-risk group that could benefit from sensitive and specific blood- or tissue-based biomarkers. We review recent work with biomarker development in MPM and literature of the last 20 years on the most promising blood- and tissue-based biomarkers. Proteomic, genomic, and epigenomic platforms are covered. SMRP is the only validated blood-based biomarker with diagnostic, monitoring and prognostic value. To strengthen development and testing of MPM biomarkers, cohorts for validation must be established by enlisting worldwide collaborations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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