| Autor: |
Jie, Sheng, Ziyue, Zu, Yugang, Zhang, Haitao, Zhu, Jianchen, Qi, Tao, Zheng, Ying, Tian, Longjiang, Zhang |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of materials chemistry. B. 10(31) |
| ISSN: |
2050-7518 |
| Popis: |
Atherosclerosis (AS) is a condition associated with dysfunctional lipid metabolism and an inflammatory immune microenvironment that remains the leading cause of severe cardiovascular events. Drugs exhibiting both anti-inflammatory and lipid-scavenging activity hold great promise for treating AS. In this study, zeolitic imidazolate framework-8 (ZIF-8) nanoparticles loaded with losartan potassium (LP) were developed as an anti-AS treatment to target both of these therapeutic arms simultaneously. LP@ZIF-8 accumulated within AS target tissues via the enhanced permeability and retention (EPR) effect, as confirmed |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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