| Autor: |
Ge-Jun, Gao, Song, Wen, Tao, Yang, Feng, Dai, Min, Wu, Feng-Chao, Zang, Yan-Li, An, Zhong-Bao, Tan |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Zhonghua yi xue za zhi. 90(4) |
| ISSN: |
0376-2491 |
| Popis: |
To investigate the methods of manganese enhanced magnetic resonance imaging in 7.0 T magnetic field for tracing corticospinal tract in rat brain in vivo.0.4 microl volume of 1 mol/L aqueous solution of MnCl(2) was injected into the primary motor cortex of 9 SD rats under stereotaxis. MRI studies were performed for tracing corticospinal tract and other coherent nerve tracts before injection and 24 hours, 48 hours, 72 hours, 7 days after injection respectively using 7.0T Micro-MRI.Corticospinal tract was visualized perfectly from primary motor cortex, thalamus, cerebral peduncle to pons at different time points after Mn(2+) administration, and the best contrast was achieved after 24-48 h. At the same time, a small quantity of Mn(2+) reached the opposite somatosensory cortex through the corpus callosum.Manganese enhanced MRI visualizes perfectly the transport of Mn(2+) through axoplasmic flow in corticospinal tracts. This method may be used to investigate the change of corticospinal tract and the functional connectivity between two sides of hemisphere in rat brain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
