| Autor: |
Iu B, Lishmanov, L N, Maslov, N V, Solenkova |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 69(2) |
| ISSN: |
0869-2092 |
| Popis: |
The state-of-the-art in investigations of the mu-opioid receptors (ORs) is reviewed. Published information on the interaction between mu-ORs and various G-proteins is summarized and data on the neutral antagonists and inverse agonists of mu-opioid receptor are generalized. The notions about the spontaneous activation of mu-ORs are considered and numerous reports on the interaction between mu-ORs and GIRK, KATP, and Kv channels are analyzed. The role of L, N, and P/Q types of Ca(2+)-channels in mu-OR-mediated intracellular signaling is discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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