Pyrrolidine-2,4-diones with affinity to the N-methyl-D-aspartate (glycine site) receptor, Part II. 5-Arylidene-pyrrolidine-2,3,4-trione 3-oximes as NMDA receptor antagonists

Autor:	H, Poschenrieder, G, Höfner, H D, Stachel
Rok vydání:	1999
Předmět:	Magnetic Resonance Spectroscopy Membranes Pyrrolidines Swine Oximes Animals Brain In Vitro Techniques Receptors N-Methyl-D-Aspartate
Zdroj:	Archiv der Pharmazie. 332(9)
ISSN:	0365-6233
Popis:	A series of oximes deriving from 5-arylidene-pyrrolidine-2,3,4-triones and pyridine-2,3,4-triones has been prepared. The presence of the tautomeric nitrosoenol was proven in solutions of alpha-ketooxime 7a. The binding affinity of the new oximes toward the N-methyl-D-aspartate (glycine site) receptor has been measured as a basis for more detailed structure-activity relationship studies. Oxime 13b showed the highest binding potency acting as glycine antagonist in nanomolar concentration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::67f95ff447d5e6ccac2474fc70507c16 https://pubmed.ncbi.nlm.nih.gov/10520300 Zobrazit plný text záznamu Plný text