Lowering of plasma cholesterol levels in animals by lovastatin and simvastatin

Autor:	Y, Chao, J S, Chen, V M, Hunt, G W, Kuron, J D, Karkas, R, Liou, A W, Alberts
Rok vydání:	1991
Předmět:	Simvastatin Cholesterol Liver Receptors LDL Anticholesteremic Agents Animals Lovastatin Hydroxymethylglutaryl-CoA Reductase Inhibitors Cells Cultured
Zdroj:	European journal of clinical pharmacology. 40
ISSN:	0031-6970
Popis:	Lovastatin and simvastatin are potent competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Key inhibit the synthesis of cholesterol in cultured HepG23 cells, rat hepatocytes and in rats. The primary target organ of cholesterol synthesis inhibition by lovastatin and simvastatin is the liver. Lovastating and simvastatin lower levels of plasma cholesterol in rats, dogs and rabbits by inhibition the endogenous cholesterol synthesis and induction of LDL receptor in the liver.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::67c835a87ae5fa8daabd0be46c872944 https://pubmed.ncbi.nlm.nih.gov/2044637 Zobrazit plný text záznamu Full text from SpringerLink